As of March 1, 2006, a new, enhanced Accutane® pregnancy risk management program called iPLEDGE has replaced the SMART® program. Prescribers and patients must register with iPLEDGE in order to prescribe or obtain prescriptions for Accutane or its generic equivalents. For more information, please visit www.iPledgeProgram.com or call the iPledge program at 1-866-495-0654.

• Prescribing Information

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